
In order to join a Bloodline, a player follow the corresponding joining quest for each bloodline, this can be found in the quest book or in the joining section under each Bloodline no this page. Bloodline Fangs are also provided as a creative only item for modpack creatores to use.
In order to leave a Bloodline, a player can use the Purity Injection. This can be crafted with an empty syringe, milk bucket and golden apple.
Bloodlines have a Skill Tree and a Rank. You can increase your Bloodline Rank by doing quests at a faction representative. This will enhance the innate aspects of the Bloodline, as well as furthering the Skill Tree.
The Bloodline Skill Tree can be accessed from Vampirism's Skill Tree Menu. Each Bloodline Skill Tree follows a general path with skills branching out from the "Bloodline Rank Skills". These are special skills that cannot be unlocked. Instead, they are automatically given when you level up your Bloodline Rank.
Additionally, skills from the Bloodline Tree require their own bloodline perk points instead of regular skill points. These are gained by doing quests from the faction representative, like the levelling quests.
Gravebounds are a unique and rare form of Vampire Hunter. They have embraced undeath to defeat their enemies, their hunger bar is replaced with a soul meter, which can only be replenished by devouring the souls of their enemies. While they do not need to eat, they have significantly reduced natural healing, reduced XP gain and worse trade prices. They make up for this with near immortality and a set of powerful abilities.
Gravebounds also require a Phylactery. If this is destroyed, their max souls will be significantly reduced. The Phylactery can also store souls using a Soul Binder, which can also be used to bind to a new Phylactery. The total amount of souls that can be stored is based on the amount of creatures devoured.
To become Gravebound, you must create both a Rending Elixir and Heinous Elixir, and create your own Phylactery. Place down the Phylactery, then drink both the Heinous Elixir and the Rending Elixir. If you die from this, you are resurrected at the Phylactery as a Gravebound
To get corrupted blood samples, you can use a stake on bloodknight vampires.
Bloodlines significantly change the way you play as a Vampire. While each new bloodline rank may come with some penalties, it will also allow you to unlock powerful new skills. Most skills, including penalties, will become more potent with higher bloodline ranks. Each bloodline comes with 4 Bloodline Ranks, enhancing their innate abilities and gaining the ability to unlock new parts of their Skill Tree.
Mobs also have Bloodlines. The type of bloodline they receive is data driven and based on spawn location. For example, Ectotherms are more likely to spawn in cold biomes, whilst Zealots are more likely to spawn deep undergorund.
In addition to this, vampires with bloodlines can have their skin texture chosen based on their bloodline available. By default, the existing vampire skins are repurposed for this, but in the future or for modpacks each bloodline can have different skills.
Some bloodlines may attack each other. For example, mobs of the Bloodknight bloodline will attack all other bloodlines. Again, this is data-driven so can be customised with a datapack.
The Noble Bloodline are typically more fragile than other vampires, they take more damage and have less health. However, the threat of the Sun and Fire is less pronounced for them.
Some of their unlockable skills include:
To become a Noble, you must already be a Rank 2 Vampire Lord. You must then craft a Lordslayer injection and find a Vampire Baron. Corrupted Blood Samples can be dropped from Vampires when killed with a Heartstriker or Heartseeker, or can be found in chests within Vampire Crypts That Vampire Baron must be brought to under 30% health, and should have the Weakness affect applied to him. Then, attack the Baron with the Lordslayer injection to become a Noble

The Zealot Bloodline are used to a life underground, and as such take significantly more sun damage. However, they need to drink less blood and can mine faster.
Some of their unlockable skills include:
Deep underground in the Deep Dark biome there are small shrine structures. In the centre, there is an altar. As a vampire, crafting and using a Zealot Ritual Catalyst on this altar will start a ritual, leading to you becoming a Zealot

The Ectotherm Bloodline live in the frigid cold and underwater. They take more fire damage and are weakened in hot areas or biomes. However, they have significantly faster swim speed and have more innate power related to their bloodline than other bloodlines. This includes gaining access to the 'Lord of Frost' action innately at Rank 2, which is further upgraded by skills
Some of their unlockable skills include:
To become an Ectotherm, you must create and drink the Freezing Elixir. Frozen Blood Samples for crafting this are found by killing Ectotherm Vampires using a Heartstriker or Heartseeker. Ectotherms are found commonly in cold biomes. The Freezing Elixir will apply a temporary effect, and if you die from Sundamage whilst submerged in shallow water and under the effects of the Elixir, you will become an Ectotherm

The Bloodknight Bloodline are a strain that primarily feast on the fresh blood of other vampires. As a result, they lose blood slower but other sources of blood are not as nourishing.
Some of their unlockable skills include:
To become a Bloodknight, you must create and drink the Heinous Elixir. Corrupted Blood Samples can be dropped from Vampires when killed with a Heartstriker or Heartseeker, or can be found in chests within Vampire Crypts. The elixir will apply many negative effects for 30 seconds, but if you survive you will become a Bloodknight